TANTIGEN: Tumor T cell Antigen Database

Tumor T cell antigen database is a data source and analysis platform for cancer vaccine target discovery focusing on human tumor antigens that contain HLA ligands and T cell epitopes. It contains 4,006 curated antigen entries representing 251 unique proteins. The database also provides information on T cell epitopes and HLA ligands with full references, gene expression profiles, antigen isoforms, and mutations. Predicted binding peptides of 15 HLA Class I and Class II alleles were also included in the database.

TANTIGEN facilitates

  • Search by keyword or T cell epitope sequence
  • BLAST against TANTIGEN
  • Multiple sequence alignment
  • Tumor antigen classification
  • Visualization of T cell epitopes
  • Real time prediction of HLA binding peptides of each tumor antigen
  • Mutation map for easy visualization of substitution mutations
  • Nomenclature of cancer antigen names used in TANTIGEN
TANTIGEN version 1.0, Dec 1, 2009. Developed by Bioinformatics Core at Cancer Vaccine Center, Dana-Farber Cancer Institute.